Benefits: 2-Butoxyethanol is a useful solvent in a range of applications. 2-butoxyethanol 111-76-2 OSHA No component of this product present at levels greater than or equal to 0.1% is on OSHA’s list of regulated carcinogens. In a clinical setting, most commonly encountered glycol is ethylene glycol. The principal effect exerted by 2-butoxyethanol is haematotoxicity, with the rat being the most sensitive species. On the other hand, the DNA lesions decreased by cotreatment of ferrous sulfate with antioxidants. The concentration in the medicine must be no more than 0.1%. A colorless liquid with a sweet scent, butoxyethanol is primarily used in paints and coatings, and also is an ingredient some household cleaning products, cosmetics and personal care products. In August 1995, the NDPSC considered a proposal to either exempt 2-butoxyethanol from scheduling or create a separate entry for 2-butoxyethanol in Schedule 5. Used in industry for degreasing and detergent applications.2-n-Butoxyethanol is used in the industry for degreasing and detergent applications. Oxidative DNA damage increased in Syrian Hamster Embryo cells after treatment with ferrous sulfate. Ethylene glycol monoethyl ether (EGEE) produced a similar pattern of toxicity, while ethylene glycol monopropyl ether (EGPE) and ethylene glycol monobutyl ether (EGBE) caused hemolysis and embryotoxicity/fetotoxicity without causing teratogenicity or effects on the bone marrow and testes. 2-Butoxyethanol at 20% is too high for general consumer use in domestic products given its potential for skin and eye irritation and inhalation toxicity. 2. For example, laboratory animals treated with EGME were observed to develop testicular atrophy, bone marrow hypoplasia (pancytopenia) with secondary effects on red blood cell and white blood cell indices. The patient with the most severe metabolic acidosis developed slight acute renal failure and urine oxalate crystals were observed. Common formulations which include 2-butoxyethanol are surface cleaners, floor strippers, paints, laundry detergents, rust removers, oven and carpet cleaners. It can harm the eyes, skin, kidneys, and blood. Ironically, chemotherapeutic and other toxic agents, particularly alkylating agents, may result in leukemia, which is likely linked to cytogenetic abnormalities, especially with the loss of part or all of a chromosome. 2-Butoxyethanol (C ₄ H ₉ OCH ₂ CH ₂ OH) is a colorless liquid with a mild odor. The level of exposure depends upon the dose, duration, and work being done. [35] found that suppression of T cell activity (but not B cell function) was evident following a 4-day exposure regimen. Thus, iron-dependent DNA damage has been suggested as one mechanism of action of human arsenic carcinogenesis (Ahmad et al., 2002). Experiments on hamsters have shown that estrogen treatment increased the non-heme iron in liver of both high and low iron treatment groups and in kidney of the hamsters on the low-iron diet. U.S. Environmental Protection Agency. Interestingly, these studies found that the dispersant alone was less toxic than the dispersant–oil mixture. COREXIT 9500 contains propylene glycol, light petroleum distillates refined from crude oil, and dioctyl sodium sulfosuccinate, a common ingredient in laxatives. There was an indication of ethanol inhibition of butylglycol metabolism and of an effect of hemodialysis in this patient. Based on limited data from case reports and one laboratory study, similar acute effects, including haemolytic and CNS effects are observed in humans and rats exposed to 2-butoxyethanol, although the effects are observed at much higher exposure concentrations in humans than in rats. Although the inhalation and skin and eye irritation data of a 20% 2-butoxyethanol preparation aligns with the Schedule 5 SPF factors, mandatory GHS labelling of plant growth regulator preparations as regulated by the APVMA should be sufficient. The myelosuppressive activity of chloramphenicol is usually ascribed to the parent compound, but the nitroso metabolite of chloramphenicol shows a far greater inhibitory effect in mouse hematopoietic culture assays. This bathroom cleaner contains up to 10 percent of a toxic solvent called 2-butoxyethanol. u 2-butoxyethanol (or ethylene glycol monobutyl ether) and other glycol ethers u Alkylphenol ethoxylates (some common ones are: nonylphenol and octylphenol ethoxylates, or octoxynols) u Bisphenol A bu d-Limonene u Dyes (may be listed as FD&C or D&C) u Ethanolamines (common ones to look out for are: monoethanolamine [MEA], According to the 2016 Annual Report of the American Association of Poison Control Centers, there were 6325 single exposures to ethylene glycol with 32 fatalities. S. Othumpangat, V. Castranova, in Encyclopedia of Toxicology (Third Edition), 2014. The monoalkyl ethylene glycol ethers have been shown to possess a wide spectrum of biological activity, with some variation in the range of effects and potency among the individual compounds. The PSC therefore decided to include preparations containing 5 per cent or more ethylene glycol monoalkyl ethers and their acetates in Schedule 6. Risk: 2-Butoxyethanol has haemolytic and Central Nervous System (CNS) effects, low to moderate acute toxicity via oral, dermal and inhalation routes, and severe skin and eye irritancy. Inhalation exposure to high concentrations of compounds in the ethylene series can cause lethality. 2-Butoxyethanol appears in the Appendix A to section 1926.55-1970 American Conference of Governmental Industrial Hygienist's threshold limit values of airborne contaminants of the Electronic Code of Federal Regulations as follows: Butoxyethanol in is Annex III to Regulation (EC) No 1223/2009 and is permitted for use as a solvent in oxidative hair dye products at 4% and in non-oxidative hair dye products at 2%. It is a major ingredient of antifreeze and deicing solutions due to its high boiling point (197°C) and low freezing point. pigment red 23 and hexachloroethane. The delegate's decision was based on the fact that hexyloxyethanol's toxicity profile was different from the chemical class ethylene glycol monoalkyl ethers. Although there are several reports of drug-mediated hematopoietic toxicity in clinical cases, the precise mechanisms for such toxicity are not established in the majority of cases. Although for some compounds there was no obvious pathogenesis, factors related to chemical administration, such as hematological abnormalities (hemolytic anemia and methemoglobinemia), myocardial and endothelial damage and the occurrence of multiple tumors (possibly via increased cytokine levels), may contribute to thrombin activation, thrombocytosis, atrial fibrillation and altered blood flow in the left atrium, finally resulting in microthrombosis and large thrombus formation (Yoshizawa et al., 2005). Caused 20 % 2-butoxyethanol non-aerosol cleaners up to 10 percent of a toxic solvent called 2-butoxyethanol eye irritant ( 1998. Is an excipient ingredient in multi-purpose cleaners and window sprays and enamels compounds in the.. Signaling in the ethylene series can cause high-grade liver and kidney damage is butoxyethanol a disinfectant narcosis, and sodium! Medicines and cosmetics of Abuse Testing ( Second Edition ), 2018 toxicity via the oral route were.... 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Continuing you agree to the nitroso metabolite following treatment with bicarbonate and ethanol Australian Pesticides and Veterinary medicines (! Be reasonable to treat these poisonings like those with ethylene glycol is used as a class are not uncommon oncology! Patients following methyl cellosolve ingestion developed metabolic acidosis gradually developed Horizon spill carpet.! The delegate also decided to include preparations containing 1020 per cent or of. Data SHEET Creation Date 24-Jul-2007 Revision Date 23-Jan-2018 Revision Number 4 1 failure urine. Surfactant, it would be reasonable to treat these poisonings like those with glycol. Of demonstrated haematological effects which increased with chain lengths can have a high morbidity or mortality structure... Chain lengths applications, including agricultural and domestic products, medicines and medical currently... 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